NOX4 and chronic obstructive pulmonary disease: Specifically, patients with age-related lung diseases (such as COPD and asthma) showed high levels of oxidative stress in the lung tissues, Thus, patients with COPD or asthma could benefit from the use of antioxidants (e.g., NAC, Nrf2 activators, NOX-4 inhibitors, MitoQ), which suppress inflammation and reduce the progression of senescence-associated pathways (196).