It is worth pointing out that during late chronic phase of disease CPA160−189-specific cells from vaccinated mice showed the ability to produce not only IFN-γ which continued to be significantly higher in comparison to PBS control (63.5 ± 19.4 vs. 18.5 ±14.3 pg/mL; p < 0.001) (Figure 4A), but also elevated levels of the counter-regulatory IL-4 and IL-10 cytokines compared to those detected during acute phase of infection (Figure 4). This evidence concerns the gene IL4 and infection.