No evident alterations and specific segregation were detected in XL-HIGM1, XIAP, LOF STAT3 (AD-HIES), and SIgAD patients (Supplementary Figures 4A,B), except for one SIgAD patient (A13) with a severe autoimmune cytopenia which segregated outside the HD area (39–42). The gene discussed is XIAP; the disease is selective IgA deficiency disease.