On the other hand, in the same 6–16 year age range three CVID patients (V2, V5, V10) with increased TN CD4+ clustered nearby but showed diverse molecular diagnosis: in V2 was reported a dominant heterozygous mutation c.2557CNT (p.Arg853*) in the NFKB2 gene, in V5 was detected a mutation in Transmembrane Activator and Calcium-Modulator and Cyclophilin-Ligand Interactor (TACI), while V10 is still without a definite diagnosis (Figure 4A). The gene discussed is PPIB; the disease is common variable immunodeficiency.