CD8A and neoplasm: These results suggest that dual-function vector may first stimulate pDCs to produce type I IFNs, which in turn activate NK cells and CD8+ T cells accompanied by suppression of Treg and MDSCs, thus priming NK- and CD8+ T cell-mediated antitumor immune responses and inhibiting tumor growth in combination with Pim-3 shRNA-mediated tumor cell apoptosis.