SIRT2 and streptococcal pneumonia: Considering that B-1 B cells cooperate to protect from pneumococcal diseases through the generation of anti-streptococcal natural antibodies by B-1a cells and the generation of acquired anticapsule response by B-1b cells (78), it will be interesting to test whether SIRT2/3−/− mice are resistant to Streptococcus pneumoniae pneumonia (79).