Therefore, considering the high basicity of its native state, RNase 1 has been mutated to insert, as well as in RNase A (299), two 31 + 32 cysteine residues to make it dimerize similarly to BS-RNase: these mutants, named HHP-RNases, displayed a remarkable antitumor activity against several types of malignant cell lines, among which cells from neuroblastoma and rhabdomyosarcoma showed the highest sensibility (307). The gene discussed is RNASE1; the disease is neuroblastoma.