TACSTD2 and brain glioma: Some of them have been tested with proteins different from RNases (202), but asymmetric reagents have been used to form active hetero-adducts involving RNases as well: in fact, ONC displayed a remarkable antitumor activity against breast cancer or brain glioma both in vitro or in mice upon its chemical conjugation with Trop-2 (or EGP-1), or, alternatively, with a chlorotoxin (203, 204).