Although previous research has demonstrated that HLA-DRβ1 influenced an immunogenic response against malaria [i.e., SPf66 (Murillo et al., 1991) and in the AMA-1 and rhoptry-associated protein (RAP2) vaccine candidates], this study determined that DRβ1 alleles did not influence Ab response to BK-SE36 or vaccinated subjects’ susceptibility to clinical malaria (Tougan et al., 2016). The gene discussed is HLA-DRB1; the disease is malaria.