It has been reported to be associated with autoimmune diseases, glioma, and other cancers (Mccauley et al., 2010; Lessard et al., 2012; Varade et al., 2012; Sheng et al., 2015; You et al., 2015; Park et al., 2017; Wagner et al., 2017); however, knowledge regarding the biological function of TMEM39A remains limited. This evidence concerns the gene TMEM39A and autoimmune disease.