GC and infection: Like HSV-1 and most other alphaherpesviruses, including EHV-1, efficient infection is initiated by a relatively unstable attachment to heparan sulfate molecules on the proteoglycan cell surface, mediated by gC and gB, followed by binding of gD to one of the specific receptors on the cell surface (Osterrieder, 1999; Spear, 2004; Azab et al., 2010).