TNF and rheumatoid arthritis: Common biologic agents used in the treatment of RA include: anti-TNF agents such as Adalimumab, Ertanacept, and Infliximab; Rituximab which targets CD20 on B-cells; Tocilizumab which targets the Anti-IL-6 receptor and more recently janus kinase (JAK) inhibitors such as Baricitinib and Tofacitinib (19).