It was reported in adipose tissue from HFD-induced obese mice that obesity-induced suppression of adiponectin expression was induced by the increased DNMT1 expression/enzymatic activity and related DNA methylation and chromatin remodeling in the adiponectin gene promoter, and could be stimulated by DNMT inhibitor with amelioration of obesity-induced glucose intolerance and insulin resistance in an adiponectin-dependent manner. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.