Previous studies indicate that effectors of the Hippo signaling system including TEAD1 and its transcriptional activator YAP are integral components of the embryonic development of human pancreas (Cebola et al., 2015) and its expression is recapitulated during progression of pancreatic disorders (Kapoor et al., 2014; Zhang et al., 2014; Morvaridi et al., 2015; Hao et al., 2017). This evidence concerns the gene YAP1 and pancreas disorder.