It was originally cloned from diploid human fibroblasts stimulated by TNF, and high levels of TSG-6 protein have been found in synovial fluids of patients with inflammatory joint disorders, as well as in the sera from bacterial sepsis and systemic lupus erythematosus patients (Day and Milner, 2019). Here, TNFAIP6 is linked to systemic lupus erythematosus.