Concerning the effect of CDE on bone metabolic index including ALP, BGP, TRAP, DPD, and cathepsin K, similar to the published data that ALP activity in OVX model group showed a non-statistically increasing trend which indicating an accelerated rate of bone turnover (Swaminathan, 2001) in postmenopausal osteoporosis, CDE treatment showed significant stimulation on ALP activity and also suppression on TRAP, DPD, and cathepsin K properties, implied that the therapeutic effect of CDE on OVX rats were mainly through inhibiting bone resorption. Here, ACP5 is linked to postmenopausal osteoporosis.