Now, in the present study, an OVX rat model which could simulate postmenopausal osteoporosis was used to investigate the anti-osteoporosis action of C. deserticola in vivo, and the proteins levels of RANKL, RANK, and TRAF6 as well as other key regulators related to bone resorption were also analyzed to estimate the possible mechanisms. The gene discussed is TNFRSF11A; the disease is osteoporosis.