LZD, vancomycin, or clindamycin significantly decreased pulmonary IL-6 and mKC levels at 4 h and the IFN-γ level at 24 h after MRSA co-infection, while the levels of IL-1β, TNF-α, and IL-12 were similar to those of the placebo group. The gene discussed is TNF; the disease is coinfection.