Neuronal loss from the anterior horn of the SC at 8 weeks P.I. in vehicle-treated NMO rats (Figure 3G) could be prevented by C16 treatment (Figure 3H) and Tie2 KI + C16 treatment (Figure 3I), albeit to a lower degree for the latter, but could not be prevented by LY294002 + C16 treatment (Figure 3J). Here, TEK is linked to neuromyelitis optica.