As a proof of concept, treatment with VEGF antagonists have shown some success in reducing choroidal neovascularization lesion size and slowing the rate of vision loss (Schlingemann and Witmer, 2009; Kinnunen and Ylä-Herttuala, 2012; Papadopoulos et al., 2012). This evidence concerns the gene VEGFA and choroidal neovascularization.