At present, gold standard therapy for wet AMD involves intravitreal administration of VEGF inhibitors such as bevacizumab, ranibizumab and aflibercept, based on the notion of VEGF being a main driver of angiogenesis (Xu and Chen, 2016; Siedlecki et al., 2017; Fogli et al., 2018). The gene discussed is VEGFA; the disease is wet macular degeneration.