For example, BDNF overexpression is associated with an increased capillary density in heart tissue and reported to exert protective effects in coronary heart disease (Lorgis et al., 2010; Jiang et al., 2011; Kaess et al., 2015; Pius-Sadowska and Machaliński, 2017). This evidence concerns the gene BDNF and coronary artery disorder.