In guinea pig Hensen cells (Kalinec et al., 2009) and HEI-OC1 cells, ANXA1 was found in the cytoplasm, with membrane localization observed only after stimulation with glucocorticoids; in contrast, Jeppesen et al. (2019) localized ANXA1 only in the plasma membrane of DKO-1 and Gli36 human cancer cells, which they used in the reported study. Here, ANXA1 is linked to cancer.