The discoveries that amyloid precursor protein (APP), the parent of amyloid beta, attaches microtubule motors to vesicular cargo for axonal transport (Kamal et al., 2000; Satpute-Krishnan et al., 2006; Seamster et al., 2012), and that tau protein binds microtubules and also plays roles in transport, have led to proposals that transport defects accompany AD, either in causative or synergistic ways (Stokin and Goldstein, 2006; Bearer, 2012). This evidence concerns the gene APP and Alzheimer disease.