Another study constructed AD and T2D networks using knowledge extracted from the scientific literature and revealed a potential interaction between the insulin signaling pathway with the neurotrophin, phosphatidylinositol 3-kinase and protein kinase B/Akt (PI3K-AKT), mammalian/mechanistic target of rapamycin (MTOR), and mitogen-activated protein kinase (MAPK) signaling pathways (Karki et al., 2017). This evidence concerns the gene INS and Alzheimer disease.