Notably, STAT3 is a pivotal mediator of the anti-inflammatory effects of IL-10 also in human macrophages (Williams et al., 2004) and is among the highly predicted target genes for the dysregulated miRNAs occurring in the peripheral blood mononuclear cells (PBMCs) of ischemic stroke patients (Bam et al., 2018). The gene discussed is IL10; the disease is ischemic stroke.