Since it has been reported that cerebral ischemia caused by Ang II is mediated through AT1R (Michel et al., 2013) and that, on the other hand, AT1R is responsible for the central and peripheral activities of Ang II (Benicky et al., 2011), the effect of candesartan, an AT1R receptor blocker, was investigated in another part of this study. The gene discussed is AGT; the disease is brain ischemia.