Although authors demonstrated that the latter two belonged to M CLL, intermediate CLL (mean load of IGHV mutation: 96.7%) was a relatively complex group with biased use of IGHV1‐18 and higher rate of SF3B1 mutation.27 Perhaps the current debate on the best IGHV cutoff values was due to the effect of this group of cells with complex performance. This evidence concerns the gene SF3B1 and B-cell chronic lymphocytic leukemia.