The frequency of CD3+CD8+ T cells and OVA-specific CD8 T cells (CD8+TCRVβ5.1+) in the total tumor-infiltrating immune cell population (CD45+ live cells) were significantly reduced in EG7-B7H4 tumors compared to EG7-mock tumors (Fig. 4a, c). The gene discussed is PTPRC; the disease is neoplasm.