In the case of Head and Neck squamous cell carcinoma (HNSC) for example, CDX2 and hsa-miR-205-5p were significantly upregulated in HNSC compared with controls (P = 2.89 × 10−3 for CDX2, P = 1.30 × 10−17 for hsa-miR-205-5p; t-test), whereas AMOT was significantly downregulated in HNSC (P = 6.23 × 10−17, t-test) (Figure 4B-D). The gene discussed is CDX2; the disease is head and neck squamous cell carcinoma.