MFN2 and hereditary motor and sensory neuropathy: Mutation in MFN2, a key MAM-mitochondria linking protein, has been associated with a broad range of motor neuron phenotypes including CMT (CMT2A2), HMSN with pyramidal features (HMSN V), HMSN with optic atrophy (HMSN VIA) and/or cognitive impairment, and spasticity (Chung et al., 2006; Feely et al., 2011; Ando et al., 2017).