Targeted inhibition of LSD1 or JMJD3 robustly impaired these above-mentioned malignant properties.15,16,23 Thus, it remains an interesting issue concerning whether combinational treatment with TCP and GSK-J1 also induces these therapeutic effects beyond cell proliferation, apoptosis and senescence in HNSCC. The gene discussed is KDM6B; the disease is head and neck squamous cell carcinoma.