The past few decades have witnessed tremendous translational significance of aberrant epigenetic dysregulation underlying tumorigenesis and epigenetic modifiers exploited as targets against cancer.5 Here we integrate the findings from in vitro experiments, in vivo animal models and bioinformatics analyses and reveal that TCP works synergistically with GSK-J1 against HNSCC by modulating genes involved in cell proliferation and apoptosis. The gene discussed is SPINK1; the disease is cancer.