Findings from clinical applications and animal studies have revealed that side effects and toxicities of LSD1 inhibitors, like monoamine oxidase inhibitors (MAOI), include orthostatic hypotension, dizziness, drowsiness, insomnia and nausea in human, as well as seizures and high mortality in animals.37,47,48 These above-mentioned challenges necessitated the explorations to design therapeutic agents or strategies to targeting LSD1 more effectively with fewer toxicities. This evidence concerns the gene KDM1A and hypotensive disorder.