These results were in line with previous reports wherein TCP exposure reduced LSD1 protein expression in oesophageal carcinoma, breast cancer and neuroblastoma,36,37 and GSK-J4 treatment resulted in decreased JMJD3 abundance in breast cancer and glioma.38,39 As expected, global increase in H3K4me2 and H3K27me3, the primary targets modified by LSD1 and JMJD3, was observed. This evidence concerns the gene KDM6B and breast carcinoma.