KDM6B and cancer: Previous findings have established that LSD1 and JMJD3 as histone-modifying enzymes execute their functions largely via demethylation of histone H3 lysines 4, 9 or 27, resulting in activation or inactivation of gene expression.19,57–59 Consistent with these findings,58,59 our RNA-seq revealed hundreds of DEGs following TCP and GSK-J1 treatment and their enrichments in multiple cancer-related biological categories and pathways.