KDM1A and cancer: Several lines of evidence have revealed that LSD1 is an essential oncogene driving cancer initiation, overgrowth and metastatic dissemination in multiple contexts including HNSCC.13,15,16 Our results together with others have provided clues that genetic or pharmacological depletion of LSD1 induces therapeutic effects in HNSCC.12,13,17 However, the potency of single-agent chemotherapy usually seems limited, as evidenced by the facts such as initially effective but acquired therapeutic resistance and toxicities when used in high dosage.