As shown in Supplementary Fig. 12A, B, LSD1 mRNA was significantly upregulated in a fraction of HNSCC samples as compared with their non-tumour counterparts (P < 0.0001), whereas JMJD3 mRNA expression in HNSCC was comparable to their non-tumour counterparts (P = 0.4764). This evidence concerns the gene KDM6B and head and neck squamous cell carcinoma.