KDM1A and central nervous system cancer: These results were in line with previous reports wherein TCP exposure reduced LSD1 protein expression in oesophageal carcinoma, breast cancer and neuroblastoma,36,37 and GSK-J4 treatment resulted in decreased JMJD3 abundance in breast cancer and glioma.38,39 As expected, global increase in H3K4me2 and H3K27me3, the primary targets modified by LSD1 and JMJD3, was observed.