Of particular interest, in periodontitis patients, IL-36γ mRNA is positively correlated with archetypal inflammatory cytokines already known to be involved in periodontitis and inflammatory diseases, i.e., IL-1β, IL-6, TNF-α and IL-17A while IL-36β or IL-36Ra are not correlated with these cytokines. The gene discussed is IL1B; the disease is periodontitis.