The aims of our work were (i) to show the gingival expression pattern of IL-36s and its role in periodontitis using human gingival samples and primary gingival cells, and (ii) to present evidence that IL-36γ support osteoclastogenesis by enhancing RANKL/OPG expression ratio in OECs. The gene discussed is TNFRSF11B; the disease is periodontitis.