Among the identified transcripts, downregulation of COL6A2, SERPINA1, CCBE1, TFPI2, THBS1 and COL8A1 have been shown to promote migration and invasion of malign breast cancer cells, aggravate metastatic spread and result in poor prognosis of breast cancer patients25,34–37. This evidence concerns the gene COL8A1 and breast carcinoma.