MAPT and Alzheimer disease: Our results reveal that the elevation of extracellular Aβ in the iPS1(P117L) and iAPP(D678H) derived neurons and the hyper-phosphorylation of Tau at Ser214 in the iAD-derived neurons compared to the control neurons (Fig. 2), suggest a recapitulation of these AD phenotypes in the AD-iPSC derived neurons.