Small interfering RNA (siRNA)-mediated ablation of LATS1, but not of LATS2, resulted in an increase of Srf-induced apoptotic cell death and a statistically significant reduction of viability in different HCC cell lines (Fig. 1a and Supplementary Fig. 1a, b), indicating a potential functional diversity between LATS1 and LATS2 in HCC. The gene discussed is LATS1; the disease is hepatocellular carcinoma.