TNFRSF1B and neoplasm: Finally, ovariectomy did not reduce the incidence of experimental LM in TNFR2−/− mice (Supplementary Fig. 2a) neither was the number of lung metastases reduced in TNFR2−/− mice (Supplementary Fig. 2b), suggesting that the tumor growth-promoting effect of ovarian hormones in the liver may be linked to TNFR2 signaling.