CDH1 and enterocolitis: Another potential limitation of the enterocolitis model is that internalin A (InlA)-dependent mechanisms of pathogenesis may not apply in this setting, because mouse E-cadherin and InlA have weak interactions (20, 21); however, dissemination in the enterocolitis model appears to follow the route described in the guinea pig model, where interactions between InlA and E-cadherin play a role (9).