In keeping with the attenuated tissue damage, the typical infection-induced increases in levels of mature IL-1β, as well as transcription of the proinflammatory cytokine Il-6 (Fig. 7A) and infiltration of Ly6G-positive neutrophils into the infected cecal mucosa, were significantly attenuated in POR2ΔvopC mice (Fig. 7B). The gene discussed is IL1B; the disease is infection.