For example, because glucose metabolism in immune cells is coordinated in part by phosphatidylinositol 3-kinase/Akt (PI3K/Akt), which posttranslationally regulates Glut1 trafficking to the cell membrane (73), experimental use of PI3K inhibitor LY294002 suppressed Glut1 surface expression and glucose uptake, leading to subsequent abrogation of HIV-1 infection of CD4+ T cells (74). The gene discussed is CD4; the disease is HIV-1 infection.