AHR knockdown significantly impaired HIV-luc/JRFL infection of Magi/CCR5 cells, HIV-luc/VSV-G infection of HEK293T cells (unpaired t test, P < 0.001) (Fig. 3D), and HIV-luc/NL4-3 infection of primary CD4+ T cells (unpaired t test, P < 0.01) (Fig. 3E, right panel). The gene discussed is CCR5; the disease is infection.