To investigate whether thermogenesis was offering any protection from metabolic disease, we examined whether housing male Ad-B2(−/−) mice at thermoneutrality would uncover the metabolic phenotype observed in global Bscl2 knockout mouse models, which typically have used male mice (Cui et al., 2011; Chen et al., 2012; Prieur et al., 2013; Mcilroy et al., 2018b). This evidence concerns the gene ITGAD and metabolic disease.