Also, GDF11 activated multiple signal pathways, such as Smad, Akt, and p38 MAPK, which were involved in the development of obesity, fatty liver, and insulin resistant [1, 20–22], implying that GDF11 may play an important role in obesity and obesity-related metabolic disorders. This evidence concerns the gene GDF11 and obesity due to melanocortin 4 receptor deficiency.