For example, PKM2 (The M2 isoform of pyruvate kinase) is essential in the metabolism and growth of tumor cells, and increased PKM2 during TGF-β1 (beta-type transforming growth factor mRNA) signaling induces epithelial–mesenchymal transition (EMT) in LUAD cells, which is a biomarker for treatment response [6, 7]. Here, PKM is linked to neoplasm.