SOD1 is a soluble Cu/Zn enzyme that is mainly located in the cytosol, although a small percentage of SOD1 proteins (~ 3%) is found in the intermembrane space of the mitochondria; SOD1 was found to decrease pso-mediated ROS in prostate cancer, inducing tumor cell growth and metastasis [27]. The gene discussed is PIPOX; the disease is prostate cancer.