With the increasing risk score of patients with lymph node metastasis of lung adenocarcinoma, the expression of high-risk mRNAs (HMMR, B4GALT1, ANGPTL4, EXT1, GPC1, RBCK1, SOD1, AGRN) was obviously upregulated. The gene discussed is ANGPTL4; the disease is metastatic malignant neoplasm in the lymph nodes.