Third, the presence of T2DM might induce different protective mechanisms, such as a more favorable lipoprotein prolife associated with elevated BNP via adiponectin signaling as cardioprotective effects [47]; and modifying myocardial response to ischemia/reperfusion mediated by dynamin-related protein 1 mitochondrial fission [48]. Here, NPPB is linked to type 2 diabetes mellitus.