Adding a combination of hs-Tnl and BNP to the risk factor model further increased the AUC to 0.75 (95% CI 0.69–0.81), incremental benefit was observed in patients without T2DM when compared with the single biomarker model (Model 5 versus Model 4: DeLong’s test, P = 0.047). This evidence concerns the gene NPPB and type 2 diabetes mellitus.