The concentrations of both SNAP-25 measures and synaptotagmin-1 were significantly positively correlated with CSF Aβ42 concentrations in the FTD biomarker group (SNAP-25tot r = 0.32; SNAP-25aa40 r = 0.35; synaptotagmin-1 r = 0.33; all p < 0.05) but not in the AD biomarker group. Here, SYT1 is linked to frontotemporal dementia.