Recent longitudinal analyses of participants within the Alzheimer’s Disease Neuroimaging Initiative (ADNI) demonstrated evidence of synergism between Aβ and phosphorylated tau (p-tau) suggesting these pathologies may interact to trigger the progression from amnestic mild cognitive impairment (MCI) subjects to AD dementia [1, 2]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.