The current study tested the immunogenicity of AV-1959R/A and AV-1980R/A as a combined vaccine in the T5x bigenic mouse model of AD which exhibits robust accumulation of intraneuronal tau and extensive extracellular amyloid plaque pathology within the hippocampus, neocortex, and amygdala by 7 months of age [11]. Here, MAPT is linked to Alzheimer disease.