Among HIV patients treated with anti-PD-(L)1 monotherapy, the incidence of any grade irAEs was 25% (hepatitis, rash, pneumonitis and hypothyroidism, n = 2 each) and grade ≥ 3 irAEs were 19% [pneumonitis (n = 2) and hepatitis (n = 1)]. Here, CD274 is linked to hepatitis A virus infection.