Our comparative and systematic genome-wide transcriptome analyses of Npc1+/+/App+/+, Npc1+/+/App−/−, Npc1−/−/App+/+, and Npc1−/−/App−/− mice at pre-symptomatic stage revealed that loss of APP function results in severe exacerbation of multiple inflammatory pathways already present in the NPC brain. The gene discussed is APP; the disease is nasopharyngeal carcinoma.