APP and nasopharyngeal carcinoma: In summary, our work revealed that loss of APP function in the NPC brain exacerbates the pathogenic neuroinflammation that occurs prior to symptomatic onset, exerting a direct impact on the four major inflammatory pathways previously identified in this mouse model of NPC, namely activation of microglia, anti-viral response, activation of T-lymphocytes, and chemotaxis of T-lymphocytes.