Compared with a single knockout mouse model of NPC (Npc1−/−/App+/+) which displayed aberrant differential expression of 60 IFN-γ-responsive genes in the pre-symptomatic stage, Npc1−/−/App−/− mouse cerebella displayed the differential expression of 262 IFN-γ-responsive genes (Fig. 2). The gene discussed is IFNG; the disease is nasopharyngeal carcinoma.