The combination of IPA Disease and Function Analysis and Upstream Analysis further identified 85 IFN-γ-responsive genes and 35 IFN-α-responsive genes related to antigen presentation in Npc1−/−/App−/− cerebella, highlighting antigen presentation as one of the main inflammatory mechanisms related to APP loss of function in the NPC brain (Additional file 10: Figure S10). Here, IFNG is linked to nasopharyngeal carcinoma.