THBS1 and infection: The mRNA level of DNMT3b in HuH-7 cells was decreased by infection of lentivirus expressing sh-DNMT3b (p < 0.05) (Fig. 4a), while that of THBS1 in HuH-7 cells infected with lentivirus expressing oe-THBS1 was increased (p < 0.05) (Fig. 4b).