NPPB and heart failure: NT‐proBNP has been developed and primarily used in the clinical contexts of diagnosis and prognosis of heart failure.5 However, in population‐based samples, low‐grade elevation in NT‐proBNP was shown to be an early marker of cardiac injury that is not yet clinically evident.6, 39 In this study, we showed markedly elevated levels of NT‐proBNP in the sample receiving treatment at a narcology clinic and intermediate elevation in the general population sample of harmful drinkers.