SMAD4 and Angelman syndrome: Interestingly, one of the seven genes (KATNAL2, SMAD4, CTCF, CACNA1D, CACNB2, UBE3A, SCN1A) from the second list interacted with three or more original clusters and settled in the middle of the network, notably UBE3A, is a well-known gene responsible for the Angelman syndrome that is considered as syndromic form of ASD [23].