CXCR1 and cancer: In a similar way, the chemokine interleukin-8 (IL-8, CXCL8) is a chemo attractant that was found to be released by cancer cells and to ulcerate cells of myeloid lineages upon binding to G protein-coupled receptors C–X–C motif chemokine receptor 1 and 2 (CXCR1 and CXCR2) [32,34], while the CCL3/CCR5 axis was shown to aid in the maintenance of immunosuppressive myeloid cells to the tumor niches [21].