Furthermore, this interpretation is in line with the hypothesis of the involvement of circadian disruptive factors in an extra effort of the suprachiasmatic nucleus (the anatomical location of the biological clock) to entrain the circadian rhythms that would affect the HPA axis, leading to a desynchronization of the circadian clock and an abnormal immune response [6], which is known to play a critical role in the etiopathogenesis of MS. The gene discussed is CLOCK; the disease is myeloid sarcoma.