Anthocyanidin supplementation in an Alzheimer’s disease mouse model resulted in improved spatial working memory, attenuated oxidative stress post-intervention via PI3K/Akt/Nrf2 (phosphorylated-phosphatidylinositol 3-kinase/Akt/nuclear factor erythroid 2-related factor 2) pathways and restored pre-synaptic proteins, suggesting one role of anthocyanidin may be in protecting against neurodegeneration [41]. Here, NFE2L2 is linked to early-onset autosomal dominant Alzheimer disease.